Wietlisbach devises exhibitions, publications and other discursive formats in the fields of contemporary photography and art.
From 2015 till 2017 she was the director of Photoforum Pasquart Biel/Bienne, following her post as a curator at the Nidwaldner Museum in Stans. She founded the independent art space sic! Raum für Kunst in Lucerne in 2007. She worked for various institutions in South Africa and the United States, lastly at the Museum of Contemporary Photography in Chicago in 2015.